Spurs could have an entire team ruled out through injury and be left with only one fit striker after a tough run of seven games in 25 days.
Tom Huddlestone (ankle), Roman Pavlyuchenko (back) and David Bentley (calf) are all doubtful after starting Tuesday's 1-1 draw with Sunderland, while eight other players are definitely sidelined.
Robbie Keane (ankle), Aaron Lennon (hamstring) and Giovani dos Santos (groin) are still out, along with captain Ledley King (groin), Jermain Defoe, Michael Dawson (both ligament damage), Jamie O'Hara (back) and Jonathan Woodgate (groin).